Prostaglandins and Platelet Aggregation in Vivo

Summary

It was shown previously that prostaglandin E₁ (PGE₁) inhibits the aggregation of blood platelets in vitro whereas PGF_1α does not; in vivo, PGE₁ inhibits in rats the action of intravenously injected adenosine diphosphate. Locally administered PGE₁ is found in the present experiment to inhibit in rats the formation and growth of platelet thrombi, induced by an electric stimulus in cortical veins. PGF_1α appeared to be inactive.

The morphology of platelet thrombi induced by an electric stimulus is shown. The probability of a primary role of erythrocytes in the formation of this type of thrombi is discussed.

• References

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